How does PrJinarc® work?

UNDERSTANDING JINARC
HOW DOES JINARC WORK?
FAQs
PATIENT DOCUMENTS

In order to understand how JINARC works, we have to first understand Autosomal Dominant Polycystic Kidney Disease (ADPKD). ADPKD is a progressive, genetic disorder that can affect how your kidneys function. The symptoms and severity of ADPKD can vary greatly from person to person, even among members of the same family. Ultimately, ADPKD may lead to kidney failure.

Total Kidney Volume

TKV

Glomerular Filtration Rate

GFR

Total Kidney Volume

TKV

Glomerular Filtration Rate

GFR

You may have been living with ADPKD for most of your life, or you could have been recently diagnosed, in any case, you can start managing your ADPKD with JINARC.

The Role of Vasopressin and JINARC in ADPKD

Cysts develop on kidneys

Cysts increase in size and number as disease progresses

Kidneys increase in size

Vasopressin (a hormone that controls water reabsorption) levels are higher in people with ADPKD, which promotes cyst growth

JINARC blocks the effects of vasopressin

Cysts develop on kidneys

Cysts increase in size and number as disease progresses

Kidneys increase in size

Vasopressin (a hormone that controls water reabsorption) levels are higher in people with ADPKD, which promotes cyst growth

JINARC blocks the effects of vasopressin

JINARC slows cyst growth and the decline of kidney function
which should help protect the kidneys from damage and failure.

Because of the way JINARC works, you will urinate more frequently during the day and night. This effect will be less pronounced over time.

Test Your Knowledge!

Cysts, vasopressin and JINARC
I'M READY

Consult your doctor with any questions about your disease and your treatment, or to find out if the advice on this website is right for you. For more information on Pr JINARC® (tolvaptan), call toll free:

1-844-2JINARC

(1-844-254-6272)

All trademarks identified by a ® or a ™
are protected trademarks (registered or unregistered) of their owners or licensors. For more information, please visit www.otsukacanadatm-mc.ca.

© Otsuka Canada Pharmaceutical Inc. All rights reserved.

OCPI-JIN-00187E

All trademarks identified by a ® or a ™
are protected trademarks (registered or unregistered) of their owners or licensors. For more information, please visit www.otsukacanadatm-mc.ca.

© Otsuka Canada Pharmaceutical Inc. All rights reserved.

OCPI-JIN-00188E

Over time, cysts (sacs filled with fluid) develop on your kidneys and may get bigger. As cysts continue to grow in number and size, your kidneys get larger. Over time, you may experience symptoms of disease progression.
Your doctor may conduct a blood test to determine your glomerular filtration rate (GFR). This test is used to measure how well your kidneys are filtering blood. Monitoring your GFR will help you and your doctor see trends and changes in your condition.